Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza
Identifieur interne : 002C01 ( Main/Exploration ); précédent : 002C00; suivant : 002C02Viral Loads and Duration of Viral Shedding in Adult Patients Hospitalized with Influenza
Auteurs : Nelson Lee ; Paul K. S. Chan [Hong Kong] ; David S. C. Hui ; Timothy H. Rainer ; Eric Wong [Hong Kong] ; Kin-Wing Choi ; Grace C. Y. Lui ; Bonnie C. K. Wong ; Rita Y. K. Wong ; Wai-Yip Lam ; Ida M. T. Chu ; Raymond W. M. Lai ; Clive S. Cockram ; Joseph J. Y. SungSource :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2009.
Abstract
BackgroundThe goal of this study was to characterize viral loads and factors affecting viral clearance in persons with severe influenza MethodsThis was a 1-year prospective, observational study involving consecutive adults hospitalized with influenza. Nasal and throat swabs were collected at presentation, then daily until 1 week after symptom onset. Real-time reverse-transcriptase polymerase chain reaction to determine viral RNA concentration and virus isolation were performed. Viral RNA concentration was analyzed using multiple linear or logistic regressions or mixed-effect models ResultsOne hundred forty-seven inpatients with influenza A (H3N2) infection were studied (mean age ± standard deviation, 72±16 years). Viral RNA concentration at presentation positively correlated with symptom scores and was significantly higher than that among time-matched outpatients (control subjects). Patients with major comorbidities had high viral RNA concentration even when presenting >2 days after symptom onset (mean ± standard deviation, 5.06±1.85 vs 3.62±2.13 log10 copies/mL; P=.005; β, +0.86 [95% confidence interval, +0.03 to +1.68]). Viral RNA concentration demonstrated a nonlinear decrease with time; 26% of oseltamivir-treated and 57% of untreated patients had RNA detected at 1 week after symptom onset. Oseltamivir started on or before symptom day 4 was independently associated with an accelerated decrease in viral RNA concentration (mean β [standard error], −1.19 [0.43] and −0.68 [0.33] log10 copies/mL for patients treated on day 1 and days 2–3, respectively; P<.05) and viral RNA clearance at 1 week (odds ratio, 0.10 [95% confidence interval, 0.03–0.35] and 0.30 [0.10–0.90] for patients treated on day 1–2 and day 3–4, respectively). Conversely, major comorbidities and systemic corticosteroid use for asthma or chronic obstructive pulmonary disease exacerbations were associated with slower viral clearance. Viral RNA clearance was associated with a shorter hospital stay (7.0 vs 13.5 days; P=.001) ConclusionPatients hospitalized with severe influenza have more active and prolonged viral replication. Weakened host defenses slow viral clearance, whereas antivirals started within the first 4 days of illness enhance viral clearance
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DOI: 10.1086/600383
Affiliations:
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Rainer</name></author><author><name sortKey="Wong, Eric" sort="Wong, Eric" uniqKey="Wong E" first="Eric" last="Wong">Eric Wong</name></author><author><name sortKey="Choi, Kin Wing" sort="Choi, Kin Wing" uniqKey="Choi K" first="Kin-Wing" last="Choi">Kin-Wing Choi</name></author><author><name sortKey="Lui, Grace C Y" sort="Lui, Grace C Y" uniqKey="Lui G" first="Grace C. Y." last="Lui">Grace C. Y. Lui</name></author><author><name sortKey="Wong, Bonnie C K" sort="Wong, Bonnie C K" uniqKey="Wong B" first="Bonnie C. K." last="Wong">Bonnie C. K. Wong</name></author><author><name sortKey="Wong, Rita Y K" sort="Wong, Rita Y K" uniqKey="Wong R" first="Rita Y. K." last="Wong">Rita Y. K. Wong</name></author><author><name sortKey="Lam, Wai Yip" sort="Lam, Wai Yip" uniqKey="Lam W" first="Wai-Yip" last="Lam">Wai-Yip Lam</name></author><author><name sortKey="Chu, Ida M T" sort="Chu, Ida M T" uniqKey="Chu I" first="Ida M. T." last="Chu">Ida M. T. 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S." last="Chan">Paul K. S. Chan</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Hong Kong</country></affiliation></author><author><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rainer, Timothy H" sort="Rainer, Timothy H" uniqKey="Rainer T" first="Timothy H." last="Rainer">Timothy H. Rainer</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wong, Eric" sort="Wong, Eric" uniqKey="Wong E" first="Eric" last="Wong">Eric Wong</name><affiliation wicri:level="4"><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Centre for Epidemiology and Biostatistics, The Chinese University of Hong Kong</wicri:regionArea><placeName><settlement type="city">Sha Tin</settlement></placeName><orgName type="university">Université chinoise de Hong Kong</orgName></affiliation></author><author><name sortKey="Choi, Kin Wing" sort="Choi, Kin Wing" uniqKey="Choi K" first="Kin-Wing" last="Choi">Kin-Wing Choi</name><affiliation><wicri:noCountry code="no comma">Medicine and Therapeutics and</wicri:noCountry></affiliation></author><author><name sortKey="Lui, Grace C Y" sort="Lui, Grace C Y" uniqKey="Lui G" first="Grace C. Y." last="Lui">Grace C. Y. Lui</name><affiliation><wicri:noCountry code="no comma">Medicine and Therapeutics and</wicri:noCountry></affiliation></author><author><name sortKey="Wong, Bonnie C K" sort="Wong, Bonnie C K" uniqKey="Wong B" first="Bonnie C. K." last="Wong">Bonnie C. K. Wong</name><affiliation><wicri:noCountry code="no comma">Medicine and Therapeutics and</wicri:noCountry></affiliation></author><author><name sortKey="Wong, Rita Y K" sort="Wong, Rita Y K" uniqKey="Wong R" first="Rita Y. K." last="Wong">Rita Y. K. Wong</name><affiliation><wicri:noCountry code="no comma">Medicine and Therapeutics and</wicri:noCountry></affiliation></author><author><name sortKey="Lam, Wai Yip" sort="Lam, Wai Yip" uniqKey="Lam W" first="Wai-Yip" last="Lam">Wai-Yip Lam</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Chu, Ida M T" sort="Chu, Ida M T" uniqKey="Chu I" first="Ida M. T." last="Chu">Ida M. T. Chu</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lai, Raymond W M" sort="Lai, Raymond W M" uniqKey="Lai R" first="Raymond W. M." last="Lai">Raymond W. M. Lai</name><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Cockram, Clive S" sort="Cockram, Clive S" uniqKey="Cockram C" first="Clive S." last="Cockram">Clive S. Cockram</name><affiliation><wicri:noCountry code="no comma">Medicine and Therapeutics and</wicri:noCountry></affiliation></author><author><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2009</date><biblScope unit="vol">200</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="492">492</biblScope><biblScope unit="page" to="500">500</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">BackgroundThe goal of this study was to characterize viral loads and factors affecting viral clearance in persons with severe influenza MethodsThis was a 1-year prospective, observational study involving consecutive adults hospitalized with influenza. Nasal and throat swabs were collected at presentation, then daily until 1 week after symptom onset. Real-time reverse-transcriptase polymerase chain reaction to determine viral RNA concentration and virus isolation were performed. Viral RNA concentration was analyzed using multiple linear or logistic regressions or mixed-effect models ResultsOne hundred forty-seven inpatients with influenza A (H3N2) infection were studied (mean age ± standard deviation, 72±16 years). Viral RNA concentration at presentation positively correlated with symptom scores and was significantly higher than that among time-matched outpatients (control subjects). Patients with major comorbidities had high viral RNA concentration even when presenting >2 days after symptom onset (mean ± standard deviation, 5.06±1.85 vs 3.62±2.13 log10 copies/mL; P=.005; β, +0.86 [95% confidence interval, +0.03 to +1.68]). Viral RNA concentration demonstrated a nonlinear decrease with time; 26% of oseltamivir-treated and 57% of untreated patients had RNA detected at 1 week after symptom onset. Oseltamivir started on or before symptom day 4 was independently associated with an accelerated decrease in viral RNA concentration (mean β [standard error], −1.19 [0.43] and −0.68 [0.33] log10 copies/mL for patients treated on day 1 and days 2–3, respectively; P<.05) and viral RNA clearance at 1 week (odds ratio, 0.10 [95% confidence interval, 0.03–0.35] and 0.30 [0.10–0.90] for patients treated on day 1–2 and day 3–4, respectively). Conversely, major comorbidities and systemic corticosteroid use for asthma or chronic obstructive pulmonary disease exacerbations were associated with slower viral clearance. Viral RNA clearance was associated with a shorter hospital stay (7.0 vs 13.5 days; P=.001) ConclusionPatients hospitalized with severe influenza have more active and prolonged viral replication. Weakened host defenses slow viral clearance, whereas antivirals started within the first 4 days of illness enhance viral clearance</div></front></TEI><affiliations><list><country><li>Hong Kong</li></country><settlement><li>Sha Tin</li></settlement><orgName><li>Université chinoise de Hong Kong</li></orgName></list><tree><noCountry><name sortKey="Choi, Kin Wing" sort="Choi, Kin Wing" uniqKey="Choi K" first="Kin-Wing" last="Choi">Kin-Wing Choi</name><name sortKey="Chu, Ida M T" sort="Chu, Ida M T" uniqKey="Chu I" first="Ida M. T." last="Chu">Ida M. T. Chu</name><name sortKey="Cockram, Clive S" sort="Cockram, Clive S" uniqKey="Cockram C" first="Clive S." last="Cockram">Clive S. Cockram</name><name sortKey="Hui, David S C" sort="Hui, David S C" uniqKey="Hui D" first="David S. C." last="Hui">David S. C. Hui</name><name sortKey="Lai, Raymond W M" sort="Lai, Raymond W M" uniqKey="Lai R" first="Raymond W. M." last="Lai">Raymond W. M. Lai</name><name sortKey="Lam, Wai Yip" sort="Lam, Wai Yip" uniqKey="Lam W" first="Wai-Yip" last="Lam">Wai-Yip Lam</name><name sortKey="Lee, Nelson" sort="Lee, Nelson" uniqKey="Lee N" first="Nelson" last="Lee">Nelson Lee</name><name sortKey="Lui, Grace C Y" sort="Lui, Grace C Y" uniqKey="Lui G" first="Grace C. Y." last="Lui">Grace C. Y. Lui</name><name sortKey="Rainer, Timothy H" sort="Rainer, Timothy H" uniqKey="Rainer T" first="Timothy H." last="Rainer">Timothy H. Rainer</name><name sortKey="Sung, Joseph J Y" sort="Sung, Joseph J Y" uniqKey="Sung J" first="Joseph J. Y." last="Sung">Joseph J. Y. Sung</name><name sortKey="Wong, Bonnie C K" sort="Wong, Bonnie C K" uniqKey="Wong B" first="Bonnie C. K." last="Wong">Bonnie C. K. Wong</name><name sortKey="Wong, Rita Y K" sort="Wong, Rita Y K" uniqKey="Wong R" first="Rita Y. K." last="Wong">Rita Y. K. Wong</name></noCountry><country name="Hong Kong"><noRegion><name sortKey="Chan, Paul K S" sort="Chan, Paul K S" uniqKey="Chan P" first="Paul K. S." last="Chan">Paul K. S. Chan</name></noRegion><name sortKey="Wong, Eric" sort="Wong, Eric" uniqKey="Wong E" first="Eric" last="Wong">Eric Wong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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